Allgemein

RECIPE: Bulletproof Approved Coconut Flour Bread

Makes 1 loaf of bread or 6-8 rolls.

Ingredients:
6 organic pasture raised eggs
100ml extra virgin olive oil or 120g grass fed butter
80ml coconut milk from a carton, no additives except xanthan or guar gum.
100g organic coconut flour
75g organic flax seeds, whole
15g baking soda
1/2 tsp salt
100g organic nuts from the green zone, crushed (optional, for mouth feel)
(walnuts, macadamias, almonds, pecans, chestnuts, hazelnuts)

Preparation:
Preheat the oven to 160 degrees. Mix the eggs, the oil or butter and the coconut milk. Then add the remaining ingredients. Mix until everything is well incorporated. Place the dough in a box mold lined with baking paper and sprinkle with other grains as desired. Then bake for 40-50 minutes. Alternatively, briefly chill the dough and then shape into 6-8 balls of the same size, place on a baking sheet and sprinkle with nuts as desired. Then bake for about 35 minutes. Allow the bread or rolls to cool completely before slicing.

Download PDF: Bulletproof Approved Coconut Flour Bread

10 – Oxaloacetate for Autophagy and AMPK Activation

Hey Guys and Gals. There is a new supplement on the block, and it might just help with keeping our kidneys from growing too much. It is called „Oxaloacetate“ and there are several products on the market, that contain it. It is part of the Krebs-Cycle, if you are interested in the details.

The main reason I suspect it will help keep cyst growth at bay, is because it mimics the effects of calorie restriction, and therefore promotes Autophagy (digesting damaged tissue/cysts!) and activates AMPK. Both of these pathways are associated with the inhibition of cyst growth in several studies I have read. Below is a talk on Oxaloacetate by one of the Scientists involved with the production of the supplements.

Oh, by the way, it also enhances cognition, improves blood glucose levels and increases lifespan in mice. 😉 I personally have ordered „Natural Dynamix, Endure DX“ which contains 250mg of oxaloacetate per capsule, and will take half a capsule with some vitamin c every day. I ordered at iherb- because they ship worldwide for extremely low cost. This way it comes out to around 25 USD per month, which I can manage. 🙂 Let me know what you guys think about this stuff and make sure to listen to the professionals (as linked below) 🙂 Heal well!

09 – Mayo Clinic Research Results on Caloric Restriction

Hey guys, it’s been a while since my last post, and I hope you have had some time to contemplate all the information I gave in the last 7 posts. I know it’s a LOT of actionable advise- but I hope you have the courage to try this stuff out. You can really turn things around, if you ask me. If you haven’t seen it, watch this video. BUT: WAIT Before you go ahead and starve yourself a little everyday like you might think you should…
I contacted the researchers already and told them I think protein restriction is the key in their results.

Also, since our bodies NEED sufficient proteindoing protein fasting for one day per week + bulletproof intermittent fasting (almost) daily seems to be a much better idea than restricting yourself every day for 24h.

So all the more confirmation for what I am proposing. 

 

MCT OIL DAMPENS THE EFFECT OF ENDOTOXIN

Now here’s some hot news for all of us. Turns out consuming MCT oil (like one would in their daily bulletproof coffee, or drizzled on meals) dampens the effect of endotoxin on the body. What does this mean for us? It means that if I am correct in assuming that endotoxin is directly triggering cyst growth, regular consumption of MCT oil should reduce endotoxin, or at least its inflammatory effects (which are mediated through triggering TNFalpha).

And this, in turn, would be yet another powerful way to reduce cyst growth for us PKD patients. I am consuming MCT oil daily since day 1 and now there is another impactful reason to keep on doing it. Easiest way to do it? Start drinking bulletproof coffee tomorrowwhile doing a 16/8 intermittent fasting regimen. Yes, you drink it in the 16 hours you’re fasting. And no, you cant skimp on the beans or butter. Butter needs to be grass-fed, beans need to be tested mold-free, MCT oil needs to be at least 70% C8 and preferably from a glass bottle. Recipe? See me make it on YouTube.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1522134/

06 – Autophagy For Recycling Your Damaged Cells

Good morning to you all! Today it’s all about recycling.

WHAT? Our PKD mechanisms of the day are Ca2+ AND Autophagy! I chose to tell you about both because they are triggered at the same time. In PKD, both Ca2+ (Intracellular Calcium) Content of your Cells, and Autophagy (recycling of damaged cells) is reduced. These are among the major factors in growing cysts.

Today I am going to sum up the three things anyone can do to increase them, and thereby possibly reduce their cyst growth. – Protein fasting. You guessed it. Protein fasting is so damn good for you if you do it right and do it once a week. There are many other positive aspects like anti-aging- it is just good for you. If you want to recycle those damaged cells (like cysts) like a boss, you have to do it right. look at bulletproofexec.com for more details on this, but the basics is this: eat less than 15grams of protein on that day. Eat safe carbs and fats, all from the bulletproof roadmap. And don’t be fooled. You can easily get 15g of protein by eating even rice and broccoli!

Plan your meal for the day in cronometer and see if you can stay below 15g. and don’t forget to meet your calorie needs. Good ideas are sweet potatoes, avocados, butter, etc. – Intermittent fasting. Yep. this one again. You really should be doing this every day 4-6 days a week. I do it 7 days a week mostly. When your body gets no protein whatsoever, it starts scavenging for damaged cells around your body to eat. And we with PKD have lots of those! so eat away, little protein-scavenging molecules. As outlined in POST#01

Keep 16-18 hours between dinner and lunch, have only bulletproof coffee for breakfast. – Ketosis When you are eating the bulletproof diet, you can be in ketosis. This is your body’s mode of running on ketones (little fat molecules) instead of glucose. It has numerous health benefits, and while you shouldn’t do it every day, you should do it for most of the week, if you have no specific contraindications. (talk to your nutritionist, as always 😉 ). How do you get into ketosis? eat 70% of your calories from fat (this sounds more difficult than it is, because fat has double the calories per gram. it is easy.) – and eat no carbohydrates. The MCT oil from bulletproof coffee helps with this. use it every day.

Ketosis is uniquely powerful in getting that calcium back into your cells (presuming you have enough. consume your daily calcium needs. check on cronometer! Supplement with calcium gluconate if needed.) – and it also gets Autophagy going! Only doing these three things got my cysts shrinking. You might to have to do some more stuff, because everyone is different, but it sure will improve your situation in many ways. Good luck to you all and heal well! 🙂

THE ROLE OF GLUCOSE IN PKD

A 2016 study found that Cysts grow in response to glucose, but at a much faster rate than healthy tissue. Just like a tumor. Blocking the Glucose with medication slowed progression. This is why the Bulletproof Diet works. You don’t use lots of glucose anymore. You use ketones.And you get healthy in the process. If this does not convince you, nothing will. It’s called the „Warburg Effect“ and PKD people suffer from it. Switch to a Ketogenic diet like the Bulletproof diet and you will most probably dramatically improve your Kidney health, just like me and many others. Don’t wait. Do it. Now. Start today. Get some Kerrygold butter.

Source:
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

people-online-with-pkd

01 – THE CASE FOR LIFESTYLE CHANGE IN PKD

… or: WHY YOUR DOCTOR DOESN’T HAVE A CLUE.

My name is Felix. I’m a biohacker. I read research and test out what works for me. Good news! My cysts have been shrinking since 2014, I’m down 7% in kidney volume and counting. Kidney function is up 40%. So finally I decided to share what I did differently, so others may benefit. I will try to make everything as clear as possible. Some things may at first seem counter-intuitive, but bear with me on this. I do have the science and the results to show for it: my largest kidney is now smaller than it was 10 years ago. If you want to understand what I did – Read all of the posts in their right order to really get informed on the matter. Start with this post. It is important that we get as many people as possible informed and educated on this matter so that they can do the best for their health. If you know someone that could benefit from this information, please send them the link to this page.

So how can we know if a certain lifestyle change will shrink your cysts? Your doctor would surely know about it, yes? Well, not so fast. Let’s think about how he would know. Almost no clinical trials have been done on any specific nutrition changes over the long-term in PKD. Why? It’s close to impossible because most people don’t want to change, and runtimes that long are very expensive. But people have been eating food forever so there must be enough data to know whats best for PKD right? Well, where would that data come from? Let’s do the math. 40% of people are connected to the internet worldwide. That’s 2.8 billion people. Of those 2.8 billion approximately 1 million have PKD. Now, how many of those have ever permanently changed their lifestyle and eating habits? Hard to know for sure. But a hint could be that only about 8% of people stick to their new year’s resolutions. So if we now take that as a basis, lets assume about 10% of those PKD people have ever changed their lifestyle and stuck with it so they could evaluate if it made favorable changes to cyst formation after a couple of years. Thats 100.000 People worldwide that have internet access, PKD and ever tried to change their lifestyle. It’s quite difficult to connect all those people, since even facebook has only been around for the past 10 years. Now these people might have tried all sorts of different diets, which might have had an impact, or not- but would they even have noticed? Would they have gotten regular ultrasounds to check their progress? Surely not all of them. And even though this is so unlikely – I have actually found the one story that was written about PKD and a ketogenic diet that worked. It was mentioned as a side note in an article on sott.net about little Kailey from Philadelphia. Quote: „Kailey’s last MRI in December showed that the 2 largest cysts have decreased in size“ So, did your doctor know? 😉

So, Felix, you say, what about all those people that have been eating according to a particular lifestyle for all their lives? They get PKD, too, dont they? Well, how do you know? Again, there is close to no data. It is possible that some kids out there raised on the perfect diet have PKD, but never get cysts so it is never discovered… think about that. This is why we have to be our own guinea pigs. Pick something you want to try. A vitamin. A lifestyle change. The Bulletproof Diet. Pick something you think might have an impact on your disease and stick to it. Because you can be damn sure that almost nothing has been extensively tried and tested for PKD. It is a rare disease. There is astonishingly little research out there considering lifestyle at ALL.

So dont be fooled by your doctor telling you there is nothing you can do. He doesn’t have a clue. How could he. There is no data on lifestyle.

If WE don’t do it- no one will. WE are the ones that will cure this disease. WE will try and see what works. WE will tell the others about it. So go ahead. Make the change. Measure YOUR progress. Make notes. Find the cure. Where to start?

Read all about the different things I have tried in the next post.

References:
https://www.sott.net/…/241599-Ketogenic-Diet-Changes-Little…

11 – HDACs and TNF-alpha

Hey Kidney friends. Today I’m gonna dive straight into the science. The next things we can do to stack the PKD cards in our favor is to block 2 things that are called „HDACs“ and „TNF-alpha“. HDAC stands for Histone-Deacetylase, that’s an enzyme and its primary job is to regulate gene expression. Yes- thats a good thing.

Because PKD is a genetic condition. This might be interesting, right? So in animal models inhibition of several HDACs resulted in a betterment of the condition. Well, surely they used some ungodly chemicals to achieve these results? Yes, they did. But why? Because chemicals can be patented- and Butter and veggies can not. That’s right. Butyric acid, which is formed in your gut when you consume lots of nonstarchy vegetables or Apple Cider Vinegar- and is even 3-4% of grassfed butter- is a well-known HDAC inhibitor. Another reason to eat your veggies.

And eat them with some Butter, too! But: don’t expect cooked butter to give you a lot of benefits. Instead let it melt on top of your steak & vegetables to enjoy all the benefits, as well as the great taste. Mmmh. Kerrygold or Anker are the most prominent brands of grass-fed butter. Grass-fed is mandatory. And once you are on that high-fat path- keep walking it, because it has been shown in studies that being in ketosis, where you burn fat for energy, (ketones instead of glucose) will also inhibit those nasty HDACs. There are even blood meters to indicate ketosis. It starts at 0.7 but you can go up way higher than that. Higher might be better. Consuming that MCT oil in your bulletproof coffee- or even in your salad will also raise Ketones in your blood stream. I told ya- go for the Bulletproof Dietit is just about perfect for us.

What was that other thing again? Thats right. TNF-alpha. Thats a very important signaling molecule abused by cystic tissue to go on building larger and larger cysts. Less TNF-alpha equals less cysts in animal studies. Butyric acid will lower it. Taking Astragalus, which is a fabulous chinese herb with many health benefits, will also lower it. Read up on it, and get yourself some 500mg of standardized extract and take it daily. Another thing you absolutely should do, is get a couple of infrared bulbs and shine them on your kidneys for half an hour every couple of days. why?

Because there has been a study on „Irradiation with Polychromatic Visible and Infrared Light“. Quote:“In three subjects characterized by elevated TNF- level, the content of other pro-inflammatory cytokines dropped 34 times as soon as 0.5 h after the single VIP-irradiation.“ 24 hours after light therapy TNF-alpha levels were ZERO.

Thats about as much bang for your buck as you can get. Thats all for today guys and gals- I hope you can gain some insight from this info and most importantly- TAKE ACTION. We have no time to lose to win the battle against this disease. Heal well! regards Yours truly, Felix Müller

LOWERING ENDOTOXIN WITH DIET

I’ve been thinking for a long time now, that LPS (Endotoxin, which is contained in the cell walls of some bacteria) is at the heart of the PKD issue and if we manage to reduce it in the blood we might see huge effects on our kidneys.

Now here are the newly added numbers for LPS in Viome , the popular gut test. My values from 2017, when I was already in good shape, vs 2019 after following the viome recommendations. Clearly, my LPS have lowered. For me, it was taking out of my diet such things as tomatoes and green beans.

It’s different for everyone. We will see how much this stuff evolves in the future. For now, I can only recommend getting a Viome test and following the recommendations. I am not affiliated with them though. Another Option is to take „Megasporebiotic“ which has been shown to reduce endotoxin in the blood by around 90% after a meal. Thanks to my friend Sarah for letting me know these numbers are now available and sending me the info on megasporebiotic.
Great stuff!

04 – Getting Your Data

Good morning! Before I continue with sharing the other molecular triggers, I will remind you of something very important. Getting your data. What data? The data on YOUR kidneys.

The next time you visit your nephrologist (maybe you should make an appointment today), get an ultrasound and ask for the following data: – size of each kidney in inches or centimeters – size of one easy-to-spot cyst on each side Be persistent. Your neph might think it is unnecessary work to get these exact measures. For all he knows, there is nothing you can do about it anyway. 😉 He might even say he can not make out where the kidney even is anymore. Be persistent. Tell him you want to track how you are doing and it is important for you to get numbers.

A printout of an easy-to-spot area would be great, too, for comparison next year. The accuracy of ultrasound is not as high as an MRI so take these results with a grain of salt.

So now you have 4 numbers and maybe even a picture. Get your report. And get a printout of all your past reports. take them home and try to understand how fast or slow your kidneys have been growing in the past, so you will know when they are growing slower the next year. (or even shrinking). Your nephrologist has never experienced shrinking PKD kidneys, so it might take a couple of years, once you are in remission, for him to recognize that something is happening.

Half a year, or one year later, visit your nephrologist again and get the same numbers. in fact, make an appointment when you are in his office. Take note of all the changes you are implementing until your next visit, so you will know what worked, and what didn’t work. Report your progress here in a couple of monthsand let’s all see how you are doing! If you apply all the nutrition and supplement principles on this page, you have a great chance of improving your situation. Not perfection, but progress is the key.
Get educated. Be persistent- and heal well!